FULL PARTNERS
(1/10/25-30/3/27) CaixaImpulse 4DBIOSTENT "An innovative lifelong stent for children with narrowed aortas" with UPC
RESUM:
SUMMARY:
Paediatric aortic coarctation is a heart condition that affects children from birth. It is caused by a narrowing during fetus development of the main artery of the body, called the aorta, which carries blood from the heart to the rest of the body. This causes serious health problems. If left untreated, patients with this condition often have a short life expectancy, usually not living past their mid-thirties. The main complications can include high blood pressure, heart failure, infections, ruptures of the artery, and bleeding in the brain.
Surgeons use open surgery, balloons, and metal tubular meshes called stents to widen the narrow part of the artery. While these treatments can help for a while, they are at risk of causing new narrowing of the artery as the child grows. Many children need repeated treatments, which can be difficult and risky. Permanent stents create additional problems because as children grow, their arteries change, but the metal does not, so more surgeries are often required.
To address these problems, this project has designed a new and advanced stent especially for children. This stent is made from a special material that can be absorbed by the body over time and can adapt as the child grows. Unlike current treatments, this new stent not only supports the artery but also helps the artery heal and develop naturally, which may reduce the need for more surgeries.
The main goal is to test this new stent in animal models and ensure it is safe and effective. At the same time, the inventors will protect the rights to this technology and prepare a business plan to help bring it to patients. This new stent could transform how children with this heart condition are treated, offering them a safer and healthier future.
IQS work:
.
CaixaReasearch news 1/10/2025
IQS news 13/10/2025
LinkedIN 15/10/2025
'12th Annual Symposium on Pediatric Device Innovation', MedTech Conference, Toronto, September 2024.
'Recent Advances and Future Perspectives in Medical Devices', Harvard's RCC, Boston, July 2024.
'Life-Sciences Technological Innovation: PolyCoarct', Deshpande Center – MIT, Boston, April 2025.
'Challenging Cases: A Legacy of Excellence - Pediatric polymeric stent evaluation: technique and 28-day outcomes in New
Zealand white rabbits', SITE, Barcelona, October 2025.
Best Oral Presentation Award for Paquito Canalejo.
'Deep Tech for a Better Future: PolyCoarct', Deep Tech Summit, Barcelona, November 2025.
'PolyCoarct: A revolutionary, long-term solution for pediatric aortic coarctation', Pediatric Investment Forum, Barcelona, November 2025.
• Francesc Canalejo-Codina; Marta Pegueroles; Andrés A. García-Granada; Jordi Martorell; Elazer R. Edelman; Mercedes Balcells;
"Integrating stent design and microstructural characterization to improve clinical outcomes of bioresorbable stents"
Materials & Design
Volume 260, December 2025, 115013 (Q1 80/438 MATERIALS SCIENCE, MULTIDISCIPLINARY, IF 7.6 y2023)“https://doi.org/10.1016/j.matdes.2025.115013”
• Francesc Canalejo-Codina; Mariola Cano-Morenilla; Jordi Martorell; Mercedes Balcells; Marta Pegueroles; Andrés A. García-Granada;
“3D printed polymeric stent design: Mechanical testing and computational modeling”
Materials & Design
Volume , October 2024 (Q1 80/438 MATERIALS SCIENCE, MULTIDISCIPLINARY, IF 7.6 y2023)“https://doi.org/10.1016/j.matdes.2024.113395”
• U.S. Provisional Application No. 63/864,568
Filed: August 15, 2025
Titled: SYSTEMS AND METHODS FOR USE AND MANUFACTURING OF AN ADAPTABLY DYNAMICSTENT
Inventors: Elazer Edelman, Mercedes Balcells, Jordi Martorell, Andrés García & Francesc Canalejo.
Applicant: Massachusetts Institute of Technology
MIT Ref.: 26143J
Q&B Ref.: 631020.00245
For any queries do not hesitate to contact:
Andres-Amador Garcia-Granada:
Via Augusta 390, 08017 Barcelona, Spain
Tel.: +34 932 672 083 / Tel.Cen.: +34 932 672 000 -ext.283
Fax: +34 932 056 266
andres.garcia@iqs.edu
www.iqs.edu
Click here for a complete list of Andres-Amador Garcia-Granada Publications.